The effects and mechanisms of transcranial ultrasound stimulation combined with cognitive rehabilitation on post-stroke cognitive impairment
Yao Wang, Fei Li, Ming-Jun He, Shang-Jie Chen
Neurological Sciences 2022, 43, 4315-4321 · 10.1007/s10072-022-05906-2
Abstract
Objective To investigate whether transcranial ultrasound stimulation (TUS) could improve post-stroke cognitive impairment (PSCI) and the potential mechanisms through which this can be achieved. Method Sixty patients with PSCI were selected and randomly divided into a control and observation group, respectively, with 30 cases in each group. Conventional cognitive rehabilitation training combined with TUS intervention was conducted in the observation group, while conventional cognitive rehabilitation training and sham-TUS stimulation were given to patients in the control group. Results The Mini-Mental State Exam, Modified Barthel Index score, P300 latency, and wave amplitude, as well as the serum brain-derived neurotrophic factor (BDNF) levels, were significantly higher in both groups after treatment compared with those before treatment (P Conclusion Transcranial ultrasound stimulation combined with conventional cognitive rehabilitation therapy improved the PSCI condition with better efficacy than conventional cognitive rehabilitation therapy only. The mechanism involved may be correlated with the upregulation of BDNF and P300 induced by TUS.
Abstract via europepmc.
Exposures
Exposure 1: Active TUS to bilateral forehead combined with cognitive rehabilitation
Target: frontal lobe — “forehead (five probes, dual-channel device)”
Device: other named manufacturer · Shengxiang Technology · 838B-M-C-II
| Waveform | not reported | |
|---|---|---|
| Fundamental frequency (kHz) | not reported | ⚑ |
| Pulse duration (ms) | not reported | |
| Pulse repetition frequency (Hz) | not reported | |
| Duty cycle (%) | not reported | |
| Sonication duration (s) | 1,200 | ✓✓✓ |
| Free-field pressure (kPa) | not reported | |
|---|---|---|
| Free-field Isppa (W/cm²) | not reported | |
| Free-field Ispta (W/cm²) | not reported | |
| In-situ estimate | not reported | |
| In-situ pressure (kPa) | not reported | |
| In-situ Isppa (W/cm²) | not reported | |
| In-situ Ispta (W/cm²) | not reported | |
| Isppa, domain unspecified (W/cm²) | 1.75 | ✓?⚑ |
Five probes with a diameter of 2 cm were placed on the forehead of each participant (dual-channel 838B-M-C-II; Shengxiang Technology). Treatment was given for 20 min once per day, for 5 days over 6 weeks, at a sound intensity of 1.75 W/cm2 in the active-TUS group; the sham-control group received sham-TUS (stimulation stopped after the first 30 s).
Flags from extraction
exposures[0].fundamental_frequency_khz— The ultrasound frequency is not stated anywhere in the paper.exposures[0].unspecified_domain.isppa_w_cm2— The paper states only a generic 'sound intensity' of 1.75 W/cm2 without specifying whether this is ISPTA or ISPPA, or the measurement domain (free-field vs in-situ).n_sessions_per_subject— The paper states treatment was given 'once per day, which lasted for 5 days over 6 weeks' - the total number of sessions is not explicitly stated and would require multiplying 5 days/week by 6 weeks, which was not done here.sham_type— The sham mechanism is only described as stimulation being 'stopped' after the first 30 s, without stating whether the transducer output was truly inactive, damped, or otherwise; classified as 'other'.direction_of_effect— Direction of effect is inferred from clinical/cognitive and biomarker (BDNF, P300) improvements rather than from a direct measure of neuronal excitability.