Dashboard

478
papers
699
exposures
152
human studies
3,157
human participants
5,587
animals
2026.09.0
archive version
2026-09-24
last built

An exposure is one anatomical target sonicated at one fundamental frequency. Papers with several targets contribute several exposures. Subject totals sum the paper-level n, excluding papers where n isn’t reported.

Papers per year

Original ultrasound exposures of neural tissue with the intent to modulate function, from 2010 onwards.

The current year is incomplete.

02040608020102011201220132014201520162017201820192020202120222023202420252026

How often each parameter is reported

Share of exposures whose paper states the value in its main text.

  • Fundamental frequency (kHz)98 %
  • Sonication duration (s)93 %
  • Pulse repetition frequency (Hz)90 %
  • Pulse duration (ms)73 %
  • Duty cycle (%)70 %
  • Pressure, any domain (kPa)54 %
  • Isppa, any domain (W/cm²)54 %
  • Ispta, any domain (W/cm²)48 %
  • Free-field pressure (kPa)29 %
  • In-situ Isppa (W/cm²)28 %
  • Free-field Isppa (W/cm²)28 %
  • In-situ pressure (kPa)27 %
  • In-situ Ispta (W/cm²)26 %
  • Free-field Ispta (W/cm²)22 %

Model system

  • rodent234
  • human healthy102
  • human patient50
  • in vitro cell50
  • ex vivo tissue36
  • nonhuman primate28
  • invertebrate12
  • large animal12
  • other vertebrate7

Target region

Top-level region of each exposure’s target.

  • frontal lobe148
  • thalamus66
  • tissue preparation65
  • peripheral nerve64
  • hippocampal formation57
  • parietal lobe46
  • other41
  • basal ganglia41
  • cingulate cortex33
  • occipital lobe29
  • whole brain or unfocused21
  • invertebrate nervous system20
  • brainstem15
  • insular cortex15

Readouts

  • behaviour217
  • histology molecular185
  • invasive electrophysiology116
  • emg mep79
  • cellular imaging76
  • eeg meg67
  • fmri59
  • other mri55
  • clinical scale41
  • autonomic physiology36
  • other21
  • cerebral haemodynamics18

Devices

  • custom-built193
  • Sonic Concepts146
  • other named manufacturer103
  • Olympus / Panametrics89
  • NeuroFUS39
  • Ultran28
  • not reported24
  • BrainSonix20
  • IGT / Imasonic19
  • Blatek12
  • Insightec10
  • Mettler5

Waveform

  • pulsed562
  • continuous114
  • theta burst36
  • not reported20
  • other patterned3

Direction of effect

  • excitatory207
  • inhibitory104
  • mixed or unclear56
  • bidirectional54
  • not assessed48
  • no effect9

Conditions

  • healthy330
  • other33
  • depression26
  • chronic pain24
  • epilepsy17
  • stroke16
  • alzheimers disease16
  • parkinsons disease16
  • substance use disorder7
  • systemic inflammation6
  • traumatic brain injury4
  • anxiety4

Sham and control

  • inactive transducer189
  • none176
  • active control site60
  • undescribed55
  • no treatment control16
  • sound only11
  • unfocused or detuned10
  • other7