Production of Reversible Changes in the Central Nervous System by Ultrasound

F. J. Fry, H. W. Ades, W. J. Fry

Science 1958, 127, 83-84 · 10.1126/science.127.3289.83

other vertebratehealthyinvasive electrophysiology

Speciescat

Subjectsnot reported animals

Sessions per subjectnot reported

Randomisednot reported

Blindingnot reported

Sham / controlnone

Auditory controlnot reported

Readout timingboth

Anaesthesianot reported

Readoutsinvasive electrophysiology — Visually-evoked cortical potentials recorded via bipolar electrodes placed in cortical areas of both hemispheres, in response to repeated light flashes

Direction of effectinhibitoryUltrasonic irradiation of the lateral geniculate nucleus reversibly suppressed the visually-evoked cortical potential: the primary response was reduced to less than one-third of its original amplitude and the secondary response to practically zero at the termination of irradiation, with complete recovery apparent 30 minutes after exposure.

Adverse eventsnot reportedThe effect was produced by a dosage of ultrasound which does not cause any histologically observable lesion in the tissue.

Exposures

Exposure 1: Ultrasonic irradiation of lateral geniculate nucleus

Target: lateral geniculate nucleus — “lateral geniculate nucleus”
Device: not reported

Pulse timing
Waveform	not reported
Fundamental frequency (kHz)	not reported	⚑
Pulse duration (ms)	not reported
Pulse repetition frequency (Hz)	not reported
Duty cycle (%)	not reported
Sonication duration (s)	20, 120swept	✓✓✓⚑

Pressure and intensity, by domain
Free-field pressure (kPa)	not reported
Free-field Isppa (W/cm²)	not reported
Free-field Ispta (W/cm²)	not reported
In-situ estimate	not reported
In-situ pressure (kPa)	not reported
In-situ Isppa (W/cm²)	not reported
In-situ Ispta (W/cm²)	not reported

Protocol, in the paper’s words

With a suitably chosen sound level and with an exposure time in the range from 20 to 120 seconds, it has been possible to produce reversible suppressions of various components of the elicited electrical response in the visual cortex. The focus of the sound beam is placed successively in and around the region of the lateral geniculate nucleus.

Flags from extraction

exposures[0].timing.sonication_duration_s — Paper gives a range (20-120 s), not a single value; represented as a two-element list [min, max].
n_subjects — Paper says results were 'obtained in a number of animals' without giving a count.
model_system — Cat is not explicitly listed under any model_system category (large_animal examples are sheep/pig/rabbit/dog); classified as other_vertebrate.
sham_type — No explicit sham condition is described; classified as 'none' because the design compares before/during/after ultrasound within the same animal rather than using a separate sham session.
exposures[0].fundamental_frequency_khz — This is a very brief communication (Science, 1 page); frequency, pressure, and intensity of the ultrasound are not stated in the available text.

Notes: This is a very short (~1 page) Science communication with minimal methodological detail. Most acoustic parameters (frequency, pressure, intensity, waveform) are not reported in the text; only the exposure duration range (20-120 s) is quantified.